Pre-Implantation Genetic Diagnosis (PGD)

Pre-implantation genetic diagnosis (PGD), also known as embryo screening, describes a variety of procedures performed on embryos prior to implantation, and sometimes even on oocytes (immature eggs) prior to fertilization. To “screen” an embryo means to test for genetic, physiological or anatomical conditions in the absence of symptoms of disease. In other words, our fertility specialists use pre-implantation genetic diagnosis prior to implantation in order to identify genetic defects within embryos created through in vitro fertilization (IVF), and to prevent certain disorders or diseases from being passed on to the baby.

pgdIn most cases of PGD, one or both partners involved have been genetically screened and identified to be carriers of potential problems that could be passed on to their child. PGD is an adjunct to assisted reproductive technology, and begins with the normal process of IVF to collect and manually fertilize eggs. Next, DNA is retrieved from the embryo and evaluated to determine if the inheritance of a problematic gene is present. Once the PGD procedure has been conducted and embryos free of genetic problems have been identified, an embryo transfer will be performed to implant the embryo in the uterus.

Pre-implantation genetic diagnosis is a procedure that can benefit any couple at risk for passing on a genetic condition or disease. Possible candidates for PGD include women 35 and older, carriers of single gene defects, carriers of sex-linked genetic disorders, women with chromosomal disorders, and women experiencing recurring pregnancy loss due to chromosomal problems. Our fertility experts at GREFI provide PGD services to patients throughout Puerto Rico, and can answer any questions you may have about how this procedure can benefit you in your pregnancy.

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